Protein Details: Cyclic nucleotide-gated ion channel 2

Protein ID

ICDB_Pro_0243

Protein Name

Cyclic nucleotide-gated ion channel 2

Gene Name

CNGC2 DND1 At5g15410 T20K14_20

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

726 amino acids

AlphaFoldDB

AF-O65718-F1-model_v4.pdb

Function

Acts as a cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium, cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis, re-establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs.

Sequence

MPSHPNFIFRWIGLFSDKFRRQTTGIDENSNLQINGGDSSSSGSDETPVLSSVECYACTQVGVPAFHSTSCDQAHAPEWRASAGSSLVPIQEGSVPNPARTRFRRLKGPFGEVLDPRSKRVQRWNRALLLARGMALAVDPLFFYALSIGRTTGPACLYMDGAFAAVVTVLRTCLDAVHLWHVWLQFRLAYVSRESLVVGCGKLVWDPRAIASHYARSLTGFWFDVIVILPVPQAVFWLVVPKLIREEKVKLIMTILLLIFLFQFLPKIYHCICLMRRMQKVTGYIFGTIWWGFALNLIAYFIASHVAGGCWYVLAIQRVASCIRQQCMRTGNCNLSLACKEEVCYQFVSPTSTVGYPCLSGNLTSVVNKPMCLDSNGPFRYGIYRWALPVISSNSLAVKILYPIFWGLMTLSTFANDLEPTSNWLEVIFSIVMVLSGLLLFTLLIGNIQVFLHAVMAKKRKMQIRCRDMEWWMKRRQLPSRLRQRVRRFERQRWNALGGEDELELIHDLPPGLRRDIKRYLCFDLINKVPLFRGMDDLILDNICDRAKPRVFSKDEKIIREGDPVQRMIFIMRGRVKRIQSLSKGVLATSTLEPGGYLGDELLSWCLRRPFLDRLPPSSATFVCLENIEAFSLGSEDLRYITDHFRYKFANERLKRTARYYSSNWRTWAAVNIQMAWRRRRKRTRGENIGGSMSPVSENSIEGNSERRLLQYAAMFMSIRPHDHLE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 531..661; /ligand="a nucleoside 3,5-cyclic phosphate"; BINDING 600; /ligand="a nucleoside 3,5-cyclic phosphate"

Disease

Location

Expressed in the whole plant but only weakly in roots. Strongly expressed in the expanded cotyledons of 14-day-old seedlings and detected later in leaves after the transition to flowering. Also detected in flowers during organ senescence and in the dehiscence zone of siliques. {ECO:0000269|PubMed:11506354}.

DOI ID

10.1104/pp.121.3.753; 10.1073/pnas.150005697; 10.1038/35048507; 10.1111/tpj.13415; 10.1046/j.1365-313x.1999.00422.x; 10.1016/s0014-5793(00)01383-1; 10.1007/s004250000510; 10.1104/pp.126.4.1646; 10.1104/pp.102.019216

RefSeq

NP_197045.1 [O65718-1]